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Self‐Liganded Suzuki–Miyaura Coupling for Site‐Selective Protein PEGylation
Author(s) -
Dumas Anaëlle,
Spicer Christopher D.,
Gao Zhanghua,
Takehana Tsuyoshi,
Lin Yuya A.,
Yasukohchi Tohru,
Davis Benjamin G.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208626
Subject(s) - pegylation , computer science , combinatorial chemistry , simple (philosophy) , chemistry , yield (engineering) , reagent , computational biology , biochemistry , biology , polyethylene glycol , organic chemistry , materials science , metallurgy , philosophy , epistemology
Building with PEGs : PEG–boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70–98 % yield. When combined with non‐natural amino acids, they allow efficient and direct, site‐selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands.