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Hydroxorhodium/Chiral Diene Complexes as Effective Catalysts for the Asymmetric Arylation of 3‐Aryl‐3‐hydroxyisoindolin‐1‐ones
Author(s) -
Nishimura Takahiro,
Noishiki Akira,
Ebe Yusuke,
Hayashi Tamio
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208593
Subject(s) - stereocenter , enantioselective synthesis , isoindoline , diene , aryl , catalysis , chemistry , dehydration , combinatorial chemistry , organic chemistry , natural rubber , alkyl , biochemistry
Water is out, aryl is in! Asymmetric synthesis of isoindoline‐1‐ones bearing an α‐triaryl‐substituted stereogenic center was realized in the enantioselective addition of arylboroxines to 3‐aryl‐3‐hydroxyisoindolin‐1‐ones in the presence of a hydroxorhodium/chiral diene catalyst, where cyclic N ‐carbonyl ketimines were generated in situ by dehydration.