Hydroxorhodium/Chiral Diene Complexes as Effective Catalysts for the Asymmetric Arylation of 3‐Aryl‐3‐hydroxyisoindolin‐1‐ones | Zendy

Nishimura Takahiro | Zendy; Noishiki Akira | Zendy; Ebe Yusuke | Zendy; Hayashi Tamio | Zendy

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Hydroxorhodium/Chiral Diene Complexes as Effective Catalysts for the Asymmetric Arylation of 3‐Aryl‐3‐hydroxyisoindolin‐1‐ones

Author(s) -

Nishimura Takahiro,

Noishiki Akira,

Ebe Yusuke,

Hayashi Tamio

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201208593

Subject(s) - stereocenter , enantioselective synthesis , isoindoline , diene , aryl , catalysis , chemistry , dehydration , combinatorial chemistry , organic chemistry , natural rubber , alkyl , biochemistry

Water is out, aryl is in! Asymmetric synthesis of isoindoline‐1‐ones bearing an α‐triaryl‐substituted stereogenic center was realized in the enantioselective addition of arylboroxines to 3‐aryl‐3‐hydroxyisoindolin‐1‐ones in the presence of a hydroxorhodium/chiral diene catalyst, where cyclic N ‐carbonyl ketimines were generated in situ by dehydration.

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