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Use of Single‐Site‐Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers
Author(s) -
Kim Anthony J.,
Boylan Nicholas J.,
Suk Jung Soo,
Hwangbo Minyoung,
Yu Tao,
Schuster Benjamin S.,
Cebotaru Liudimila,
Lesniak Wojciech G.,
Oh Joon Seok,
Adstamongkonkul Pichet,
Choi Ashley Y.,
Kannan Rangaramanujam M.,
Hanes Justin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208556
Subject(s) - peg ratio , mucus , nanoparticle , polymer , coating , dna , nanotechnology , penetration (warfare) , surface modification , materials science , chemistry , biochemistry , organic chemistry , biology , ecology , finance , operations research , engineering , economics
Mucus‐penetrating DNA nanoparticles : A novel synthetic strategy was used to achieve a dense PEG coating on the surface of cationic polymer‐based DNA nanoparticles. The dense PEG coating (blue in scheme) endows the nanoparticles with a muco‐inert surface, which enables their rapid mucus penetration (trajectory indicated by gray line) and provides efficient gene transfer in various cell types.