An Air‐Stable Copper Reagent for Nucleophilic Trifluoromethylthiolation of Aryl Halides | Zendy

Weng Zhiqiang | Zendy; He Weiming | Zendy; Chen Chaohuang | Zendy; Lee Richmond | Zendy; Tan Davin | Zendy; Lai Zhiping | Zendy; Kong Dedao | Zendy; Yuan Yaofeng | Zendy; Huang KuoWei | Zendy

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An Air‐Stable Copper Reagent for Nucleophilic Trifluoromethylthiolation of Aryl Halides

Author(s) -

Weng Zhiqiang,

He Weiming,

Chen Chaohuang,

Lee Richmond,

Tan Davin,

Lai Zhiping,

Kong Dedao,

Yuan Yaofeng,

Huang KuoWei

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201208432

Subject(s) - trifluoromethyl , reagent , aryl , halide , nucleophile , copper , combinatorial chemistry , chemistry , organic chemistry , catalysis , alkyl

A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF 2 with Me 3 SiCF 3 and S 8 (see scheme; Cu red, F green, N blue, S yellow). These air‐stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields.

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