Premium
An Air‐Stable Copper Reagent for Nucleophilic Trifluoromethylthiolation of Aryl Halides
Author(s) -
Weng Zhiqiang,
He Weiming,
Chen Chaohuang,
Lee Richmond,
Tan Davin,
Lai Zhiping,
Kong Dedao,
Yuan Yaofeng,
Huang KuoWei
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208432
Subject(s) - trifluoromethyl , reagent , aryl , halide , nucleophile , copper , combinatorial chemistry , chemistry , organic chemistry , catalysis , alkyl
A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF 2 with Me 3 SiCF 3 and S 8 (see scheme; Cu red, F green, N blue, S yellow). These air‐stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields.