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Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo
Author(s) -
Han HeeSun,
Martin John D.,
Lee Jungmin,
Harris Daniel K.,
Fukumura Dai,
Jain Rakesh K.,
Bawendi Moungi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208331
Subject(s) - nanoparticle , in vivo , charge (physics) , nanotechnology , quantum dot , surface charge , set (abstract data type) , chemistry , computer science , biophysics , materials science , physics , biology , genetics , quantum mechanics , programming language
Detailed arrangements : A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.