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Enantioselective Iridium‐Catalyzed Hydrogenation of 1‐ and 3‐Substituted Isoquinolinium Salts
Author(s) -
Ye ZhiShi,
Guo RanNing,
Cai XianFeng,
Chen MuWang,
Shi Lei,
Zhou YongGui
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208300
Subject(s) - enantioselective synthesis , iridium , catalysis , enantiomer , hydride , chemistry , asymmetric hydrogenation , combinatorial chemistry , antispasmodic , ligand (biochemistry) , solifenacin , medicinal chemistry , organic chemistry , hydrogen , receptor , biochemistry , medicine , alternative medicine , pathology , pharmacology , overactive bladder
Asymmetric hydrogenation : The title reaction provides an efficient and rapid access to chiral 1‐ and 3‐substituted 1,2,3,4‐tetrahydroisoquinolines with excellent enantioselectivity (see scheme; L=ligand). A preliminary mechanistic study indicates that the 1,2‐hydride addition might be the initial step in the reaction. The method has been used in the synthesis of urinary antispasmodic drug (+)‐solifenacin.
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