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Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles
Author(s) -
Zhong Fangrui,
Dou Xiaowei,
Han Xiaoyu,
Yao Weijun,
Zhu Qiang,
Meng Yuezhong,
Lu Yixin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208285
Subject(s) - bifunctional , phosphine , michael reaction , chemistry , catalysis , aryl , combinatorial chemistry , organic chemistry , alkyl
Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3‐substituted oxindoles to activated alkenes (see scheme). Biologically relevant chiral 3,3‐disubstituted oxindoles were thus prepared in high yields and with excellent enantioselectivities from 3‐aryl‐ and 3‐alkyl‐substituted oxindoles and various activated alkenes.