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Supramolecular Control of Enzyme Activity through Cucurbit[8]uril‐Mediated Dimerization
Author(s) -
Dang Dung T.,
Nguyen Hoang D.,
Merkx Maarten,
Brunsveld Luc
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208239
Subject(s) - supramolecular chemistry , computer science , enzyme activator , chemistry , caspase , enzyme , world wide web , computational biology , biochemistry , apoptosis , biology , molecule , organic chemistry , programmed cell death
At the double : Cucurbit[8]uril‐mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N‐terminal FGG motif allows for a supramolecular‐mediated 50‐fold enhancement of caspase‐9 catalytic activity.
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