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New Insights into Gene Regulation—High‐Resolution Structures of Cobalamin Riboswitches
Author(s) -
Soulière Marie F.,
Haller Andrea,
Santner Tobias,
Micura Ronald
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208167
Subject(s) - riboswitch , adenosylcobalamin , transcription (linguistics) , computational biology , genetics , cobalamin , biology , gene , rna , folding (dsp implementation) , gene expression , non coding rna , biochemistry , electrical engineering , linguistics , philosophy , vitamin b12 , engineering
The complex class of cobalamin‐sensitive riboswitches use a “kissing loop” to regulate gene expression. The molecular details of the recognition and folding mode of this riboswitch have been revealed by recent X‐ray structures. These insights, together with the identification of RNA polymerase pause sites during transcription, have resulted in a more complete understanding of the response mechanism. AdoCbl=adenosylcobalamin.