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Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87‐MG Tumor Cells
Author(s) -
Cho Eun Chul,
Zhang Yu,
Cai Xin,
Moran Christine M.,
Wang Lihong V.,
Xia Younan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208096
Subject(s) - nanocages , in vivo , in vitro , nanoparticle , photoacoustic imaging in biomedicine , chemistry , computer science , nanotechnology , microscopy , microbiology and biotechnology , biophysics , materials science , biology , biochemistry , medicine , pathology , physics , optics , genetics , catalysis
Not always equal : When a mother cell that contains Au nanocages divides, the nanoparticles are unequally distributed between the two daughter cells. This unequal distribution of nanoparticles as well as their clearance from the cells (see picture) is quantitatively analyzed both in vitro and in vivo using two‐photon microscopy and photoacoustic microscopy, respectively.