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Systemic Delivery of microRNA‐34a for Cancer Stem Cell Therapy
Author(s) -
Shi Sanjun,
Han Lu,
Gong Tao,
Zhang Zhirong,
Sun Xun
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208077
Subject(s) - microrna , solid lipid nanoparticle , cancer , in vitro , computer science , cancer research , medicine , drug delivery , chemistry , nanotechnology , materials science , biochemistry , gene
Delivered : A solid lipid nanoparticle (SLN) system was developed to deliver microRNA‐34a (miR‐34a) relevant for cancer stem cell (CSC) therapy into lung tissues. In miR‐34a‐containing SLNs (miSLNs‐34a), miR‐34a is protected from degradation in the serum and its cellular‐transfection efficiency in vitro is increased. Thus, treatment with miSLNs‐34a results in a higher probability of survival of CSC‐bearing mice (see picture).