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Physicochemical Properties of Protein‐Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion
Author(s) -
Chanana Munish,
Rivera_Gil Pilar,
CorreaDuarte Miguel A.,
LizMarzán Luis M.,
Parak Wolfgang J.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201208019
Subject(s) - internalization , colloidal gold , nanoparticle , nanotechnology , proteolytic enzymes , chemistry , drug delivery , biological fluids , intracellular , biochemistry , materials science , enzyme , chromatography , cell
What's going on in there?! Little is known about the fate of nanoparticles (NPs) after their internalization by cells and organisms. Protein‐coated gold NPs were used to study the physicochemical properties of NPs in extra‐ and intracellular fluids. These potential vehicles for enzymatic drug delivery were highly stable at pH 7.4 in the presence of salts and free proteins, but agglomerated reversibly under acidic conditions (see picture).