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Photothermally Activated Hybrid Films for Quantitative Confined Release of Chemical Species
Author(s) -
Matteini Paolo,
Tatini Francesca,
Luconi Lapo,
Ratto Fulvio,
Rossi Francesca,
Giambastiani Giuliano,
Pini Roberto
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207986
Subject(s) - nanorod , photothermal therapy , nanotechnology , micelle , chemistry , computer science , materials science , aqueous solution , organic chemistry
Illuminating films of a porous chitosan matrix containing gold nanorods and thermosensitive micelles loaded with a chemical stimulates local photothermal conversion of the gold nanorods. The heat produced activates the ejection of the chemical from the micelles (see scheme), and causes the transient permeabilization of adjacent cell membranes, resulting in a selective cellular uptake of the released chemical with control over spatiotemporal parameters and dosage.