Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation | Zendy

He Chuan | Zendy; Ke Jie | Zendy; Xu Huan | Zendy; Lei Aiwen | Zendy

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Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation

Author(s) -

He Chuan,

Ke Jie,

Xu Huan,

Lei Aiwen

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201207970

Subject(s) - transmetalation , sonogashira coupling , limiting , catalysis , kinetic energy , chemistry , rate determining step , coupling (piping) , reaction rate , palladium , combinatorial chemistry , photochemistry , materials science , organic chemistry , physics , metallurgy , engineering , mechanical engineering , quantum mechanics

Rate‐limiting : The transmetalation step of the Sonogashira coupling reaction has been established as the rate‐limiting step. This cross‐coupling has been demonstrated to be a Pd‐catalyzed and Cu‐catalyzed synergistic process, which exhibits a first‐order kinetic dependence on both the [Pd] and [Cu] catalysts (see scheme).

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