Premium
Synergistic Catalysis in the Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation
Author(s) -
He Chuan,
Ke Jie,
Xu Huan,
Lei Aiwen
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207970
Subject(s) - transmetalation , sonogashira coupling , limiting , catalysis , kinetic energy , chemistry , rate determining step , coupling (piping) , reaction rate , palladium , combinatorial chemistry , photochemistry , materials science , organic chemistry , physics , metallurgy , engineering , mechanical engineering , quantum mechanics
Rate‐limiting : The transmetalation step of the Sonogashira coupling reaction has been established as the rate‐limiting step. This cross‐coupling has been demonstrated to be a Pd‐catalyzed and Cu‐catalyzed synergistic process, which exhibits a first‐order kinetic dependence on both the [Pd] and [Cu] catalysts (see scheme).