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The Importance of Additive and Non‐Additive Mutational Effects in Protein Engineering
Author(s) -
Reetz Manfred T.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207842
Subject(s) - protein engineering , directed evolution , chemistry , biochemical engineering , computational biology , enzyme , biochemistry , combinatorial chemistry , microbiology and biotechnology , biology , engineering , gene , mutant
Additive or non‐additive, that is the question : The increasing awareness of non‐additive cooperative mutational effects in protein engineering is currently providing new theoretical and practical insights. In particular, the directed evolution of stereoselective enzymes as catalysts in organic chemistry and biotechnology profits from this intriguing development.