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Back Cover: Ceria Nanoparticles that can Protect against Ischemic Stroke (Angew. Chem. Int. Ed. 44/2012)
Author(s) -
Kim Chi Kyung,
Kim Taeho,
Choi InYoung,
Soh Min,
Kim Dohoung,
Kim YoungJu,
Jang Hyunduk,
Yang HyeSung,
Kim Jun Yup,
Park HongKyun,
Park Seung Pyo,
Park Sangseung,
Yu Taekyung,
Yoon ByungWoo,
Lee SeungHoon,
Hyeon Taeghwan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207798
Subject(s) - nanoparticle , reactive oxygen species , in vivo , apoptosis , oxygen , int , ischemic stroke , chemistry , materials science , biophysics , nanotechnology , medicine , ischemia , biochemistry , computer science , biology , organic chemistry , microbiology and biotechnology , operating system
Ceria nanoparticles are known to exhibit free‐radical scavenging activity by reversibly binding oxygen. In their Communication on page 11039 ff. , S.‐H. Lee, T. Hyeon, et al. show that discrete, uniform 3 nm PEGylated ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species and reducing apoptosis. Optimal doses of ceria nanoparticles reduce infarct volumes and the rate of ischemic cell death, and target the infarct site in vivo.