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Back Cover: A Phenylboronate‐Functionalized Polyion Complex Micelle for ATP‐Triggered Release of siRNA (Angew. Chem. Int. Ed. 43/2012)
Author(s) -
Naito Mitsuru,
Ishii Takehiko,
Matsumoto Akira,
Miyata Kanjiro,
Miyahara Yuji,
Kataoka Kazunori
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207797
Subject(s) - chemistry , micelle , moiety , small interfering rna , biophysics , cover (algebra) , nanotechnology , rna , biochemistry , materials science , stereochemistry , biology , organic chemistry , mechanical engineering , aqueous solution , engineering , gene
Delivery of small interfering RNA is described by K. Kataoka et al. in their Communication on page 10751 ff. siRNA encapsulated in a phenylboronate‐functionalized polyion complex micelle shows specific binding between the pendent phenylboronate and the 3′‐ribose moiety of the siRNA, stabilizing the complex under extracellular conditions. This complex is disrupted upon addition of ATP at a concentration comparable to that inside cells.