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Inside Cover: Selective RNA Versus DNA G‐Quadruplex Targeting by In Situ Click Chemistry (Angew. Chem. Int. Ed. 44/2012)
Author(s) -
Di Antonio Marco,
Biffi Giulia,
Mariani Angelica,
Raiber EunAng,
Rodriguez Raphaël,
Balasubramanian Shankar
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207794
Subject(s) - rna , click chemistry , in situ , context (archaeology) , g quadruplex , dna , cover (algebra) , chemistry , small molecule , computational biology , rational design , biophysics , nanotechnology , biology , combinatorial chemistry , biochemistry , materials science , engineering , organic chemistry , gene , paleontology , mechanical engineering
The rational design of small molecules to selectively target a defined RNA is highly challenging. Such probes ultimately provide the means to interrogate RNA functions within a cellular context with high temporal resolution. In their Communication on page 11073 ff., R. Rodriguez, S. Balasubramanian, and co‐workers report the use of in situ click chemistry to identify a small molecule that selectively interacts with the telomeric repeat‐containing RNA (TERRA) through recognition of the G‐quadruplex structure. The same approach was used to identify a related analogue that targets its DNA counterpart with high efficiency.
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