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Ether‐Directed ortho ‐C–H Olefination with a Palladium(II)/Monoprotected Amino Acid Catalyst
Author(s) -
Li Gang,
Leow Dasheng,
Wan Li,
Yu JinQuan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207770
Subject(s) - palladium , catalysis , ether , chemistry , molecule , amino acid , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , biochemistry
Weak coordination is powerful! A Pd II ‐catalyzed olefination of ortho ‐CH bonds of arenes directed by weakly coordinating ethers is developed by using monoprotected amino acid (MPAA) ligands. This finding provides a method for chemically modifying ethers, which are abundant in natural products and drug molecules. HFIP=hexafluoroisopropanol.
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