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“On Water”: Efficient Iron‐Catalyzed Cycloaddition of Aziridines with Heterocumulenes
Author(s) -
Sengoden Mani,
Punniyamurthy Tharmalingam
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207746
Subject(s) - aqueous suspension , catalysis , cycloaddition , suspension (topology) , substrate (aquarium) , aqueous medium , scope (computer science) , chemistry , aqueous solution , combinatorial chemistry , reaction conditions , organic chemistry , computer science , mathematics , biology , ecology , homotopy , pure mathematics , programming language
In suspension : The reaction of aziridines with heterocumulenes in the presence of Fe(NO 3 ) 3 ⋅9 H 2 O in aqueous suspension provides access to functionalized five‐membered heterocycles in good to high yields. This protocol has a wide substrate scope, is simple, and uses a nontoxic and cheap catalyst.