A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria | Zendy

Chen Yuncong | Zendy; Zhu Chengcheng | Zendy; Yang Zhenghao | Zendy; Chen Junjie | Zendy; He Yafeng | Zendy; Jiao Yang | Zendy; He Weijiang | Zendy; Qiu Lin | Zendy; Cen Jiajie | Zendy; Guo Zijian | Zendy

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A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria

Author(s) -

Chen Yuncong,

Zhu Chengcheng,

Yang Zhenghao,

Chen Junjie,

He Yafeng,

Jiao Yang,

He Weijiang,

Qiu Lin,

Cen Jiajie,

Guo Zijian

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201207701

Subject(s) - hydrogen sulfide , fluorescence , sulfide , mitochondrion , chemistry , photochemistry , biophysics , biochemistry , biology , organic chemistry , physics , optics , sulfur

Quick : An exogenously induced quick increase of the H 2 S concentration (80 s) in MCF‐7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that can target mitochondria. CouMC was constructed by combining merocyanine and coumarin fluorophores. The selective nucleophilic addition of HS − to the merocyanine derivative at neutral pH is crucial for the rapid H 2 S detection.

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