Substrate Specificity in Ketosynthase Domains from  trans‐ AT Polyketide Synthases | Zendy

Jenner Matthew | Zendy; Frank Sarah | Zendy; Kampa Annette | Zendy; Kohlhaas Christoph | Zendy; Pöplau Petra | Zendy; Briggs Geoff S. | Zendy; Piel Jörn | Zendy; Oldham Neil J. | Zendy

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Substrate Specificity in Ketosynthase Domains from trans‐ AT Polyketide Synthases

Author(s) -

Jenner Matthew,

Frank Sarah,

Kampa Annette,

Kohlhaas Christoph,

Pöplau Petra,

Briggs Geoff S.,

Piel Jörn,

Oldham Neil J.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201207690

Subject(s) - polyketide , steric effects , residue (chemistry) , stereochemistry , branching (polymer chemistry) , chemistry , substrate specificity , substrate (aquarium) , biochemistry , biology , biosynthesis , enzyme , organic chemistry , ecology

Branching out : The substrate specificity profiles for a range of ketosynthase (KS) domains from trans ‐AT PKSs are reported. Evidence is provided that a sterically demanding amino acid residue adjacent to the active‐site Cys residue confers specificity towards non‐β‐methyl‐branched substrates (see scheme).

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