Premium
Non‐Enzymatic Dynamic Kinetic Resolution of Secondary Aryl Alcohols: Planar Chiral Ferrocene and Ruthenium Catalysts in Cooperation
Author(s) -
DíazÁlvarez Alba E.,
MesasSánchez Laura,
Dinér Peter
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207648
Subject(s) - kinetic resolution , ruthenium , racemization , aryl , catalysis , chemistry , ferrocene , yield (engineering) , organic chemistry , derivative (finance) , combinatorial chemistry , enantioselective synthesis , materials science , alkyl , electrode , economics , financial economics , metallurgy , electrochemistry
“Ruth” helps iron! A novel method for the non‐enzymatic dynamic kinetic resolution (DKR) of secondary aryl alcohols by the use of the planar chiral ferrocene derivative (+)‐ 1 in combination with the ruthenium racemization catalyst 2 yields acetylated alcohols in high enantioselectivity and yield. This development opens opportunities for new developments in the field of non‐enzymatic dynamic kinetic resolution.