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Cover Picture: Multivalency as a Chemical Organization and Action Principle (Angew. Chem. Int. Ed. 42/2012)
Author(s) -
Fasting Carlo,
Schalley Christoph A.,
Weber Marcus,
Seitz Oliver,
Hecht Stefan,
Koksch Beate,
Dernedde Jens,
Graf Christina,
Knapp ErnstWalter,
Haag Rainer
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207626
Subject(s) - indigo , chemistry , biophysics , art , biology , visual arts
Multivalent binding of dendritic polyglycerolsulfate (dPGS) to the surface‐exposed adhesion receptor L‐selectin shields white blood cells from contacting activated vascular endothelium. In the case of overwhelming inflammation, dPGS treatment strongly inhibits leukocyte emigration and thus acts as a highly effective anti‐inflammatory compound. Further information on the topic of multivalency can be found in the Review by R. Haag et al. on page 10472 ff. The cover picture was designed by Dipl.‐Chem. Achim Wiedekind, with the background based on a graphic from Juan Gaertner/shutterstock.com.