Premium
Chemistry as an Expanding Resource in Protein Science: Fully Synthetic and Fully Active Human Parathyroid Hormone‐Related Protein (1 – 141)
Author(s) -
Li Jianfeng,
Dong Suwei,
Townsend Steven D.,
Dean Thomas,
Gardella Thomas J.,
Danishefsky Samuel J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207603
Subject(s) - chemistry , parathyroid hormone , peptide , computational biology , computer science , biochemistry , combinatorial chemistry , library science , biology , calcium , organic chemistry
The convergent synthesis of human parathyroid hormone‐related protein (hPTHrP, see scheme) has been accomplished through iterative peptide ligations followed by global metal‐free dethiylation. The biological activity of synthetic PTHrP has been demonstrated.