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Small‐Molecule Lipid‐Bilayer Anion Transporters for Biological Applications
Author(s) -
Busschaert Nathalie,
Gale Philip A.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207535
Subject(s) - lipid bilayer , transporter , transmembrane protein , bilayer , chemistry , small molecule , biophysics , ion channel , nanotechnology , ion transporter , biological membrane , microbiology and biotechnology , biochemistry , membrane , biology , materials science , receptor , gene
The development of small‐molecule lipid‐bilayer anion transporters for potential future use in channel replacement therapy for the treatment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treating cancer by perturbing chemical gradients within cells, thus triggering apoptosis, is an area of intense current interest. This Minireview looks at recent developments in the design of small‐molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems.