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Enantioselective Synthesis of Carbocycles and Heterocycles by Radical/Polar and Polar/Radical Cascades
Author(s) -
Mondal Shovan,
Bertrand Michèle P.,
Nechab Malek
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207518
Subject(s) - enantioselective synthesis , polar , cascade , trimethylsilyl , chemistry , radical cyclization , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , physics , chromatography , astronomy
Radically efficient : New and appealing enantioselective cyclizations leading to highly functionalized carbocycles and heterocycles have been reported (see scheme; TMS=trimethylsilyl). These methodologies, based on the cascade combination of radical and polar steps, provide alternatives to conventional methodologies.