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Pd‐Catalyzed CH Oxygenation with TFA/TFAA: Expedient Access to Oxygen‐Containing Heterocycles and Late‐Stage Drug Modification
Author(s) -
Shan Gang,
Yang Xinglin,
Ma Linlin,
Rao Yu
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207458
Acid brings the oxygen : A general method for palladium‐catalyzed CH oxygenation has been developed for the facile synthesis of a wide range of functionalized phenols with readily available aryl ketones, benzoates, benzamides, acetanilides, and sulfonamides. A trifluoroacetic acid/trifluoroacetic acid anhydride solvent system serves as the oxygen source and is the critical factor for CH activation.