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Reversible Sensing of the Anticoagulant Heparin with Protamine Permselective Membranes
Author(s) -
Crespo Gastón A.,
Afshar Majid Ghahraman,
Bakker Eric
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207444
Subject(s) - protamine , heparin , anticoagulant , chemistry , membrane , chromatography , antidote , biochemistry , medicine , organic chemistry , toxicity
A permselective membrane electrode allows the rapid and operationally reversible detection of the polycationic polypeptide protamine in physiological samples. Anticoagulant levels of heparin can be measured in undiluted whole blood by adding a known excess of its antidote protamine to discrete blood samples.