Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium‐Catalyzed Aerobic Oxidative Isocyanide Insertion | Zendy

Vlaar Tjøstil | Zendy; Cioc Razvan C. | Zendy; Mampuys Pieter | Zendy; Maes Bert U. W. | Zendy; Orru Romano V. A. | Zendy; Ruijter Eelco | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium‐Catalyzed Aerobic Oxidative Isocyanide Insertion

Author(s) -

Vlaar Tjøstil,

Cioc Razvan C.,

Mampuys Pieter,

Maes Bert U. W.,

Orru Romano V. A.,

Ruijter Eelco

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201207410

Subject(s) - isocyanide , oxidative phosphorylation , catalysis , palladium , chemistry , combinatorial chemistry , organic chemistry , biochemistry

O 2 in, H 2 O out : Various diamines and related bisnucleophiles readily undergo oxidative isocyanide insertion with Pd(OAc) 2 (1 mol %) as the catalyst and O 2 as the terminal oxidant to give a diverse array of medicinally relevant N heterocycles. The utility of this highly sustainable method is demonstrated by a formal synthesis of the antihistamines astemizole and norastemizole.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research