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Catalytic [4+2] Cyclization of α,β‐Unsaturated Acyl Chlorides with 3‐Alkylenyloxindoles: Highly Diastereo‐ and Enantioselective Synthesis of Spirocarbocyclic Oxindoles
Author(s) -
Shen LiTao,
Jia WenQiang,
Ye Song
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207405
Subject(s) - enantioselective synthesis , catalysis , chemistry , organic chemistry , combinatorial chemistry
Cinchona alkaloids were used as Lewis base catalysts in the title reaction. The [4+2] cyclization of α,β‐unsaturated acyl chlorides with electron‐deficient alkenes derived from oxindole gave the corresponding spirocarbocyclic oxindoles.