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Streamlining Chemical Probe Discovery: Libraries of “Fully Functionalized” Small Molecules for Phenotypic Screening
Author(s) -
Oeljeklaus Julian,
Kaschani Farnusch,
Kaiser Markus
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207306
Subject(s) - phenotypic screening , small molecule , phenotype , identification (biology) , nanotechnology , computational biology , chemical library , combinatorial chemistry , chemistry , materials science , biology , biochemistry , gene , botany
Cross‐linked : The concept of phenotypic screening with probes of fully functionalized small molecules (see picture) has recently been introduced. This approach significantly increases the efficiency and success of target identification after the screening campaign.