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Organocatalytic Synthesis of Highly Substituted Furfuryl Alcohols and Amines
Author(s) -
Clark J. Stephen,
Boyer Alistair,
Aimon Anthony,
Engel García Paloma,
Lindsay David M.,
Symington Andrew D. F.,
Danoy Yves
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207300
Subject(s) - tetrahydrothiophene , domino , organocatalysis , nucleophile , chemistry , computer science , process (computing) , combinatorial chemistry , organic chemistry , catalysis , enantioselective synthesis , programming language
Top cat ! Tetrahydrothiophene is an efficient organocatalyst for the synthesis of highly substituted furfuryl products from readily accessible electron‐poor enynes under neutral reaction conditions. This process is applicable to a wide range of nucleophiles and enynes and can be used in a domino organocatalysis sequence.