Gold‐Catalyzed Formal 1,6‐Acyloxy Migration Leading to 3,4‐Disubstituted Pyrrolidin‐2‐ones | Zendy

Hashmi A. Stephen K. | Zendy; Yang Weibo | Zendy; Yu Yang | Zendy; Hansmann Max M. | Zendy; Rudolph Matthias | Zendy; Rominger Frank | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Gold‐Catalyzed Formal 1,6‐Acyloxy Migration Leading to 3,4‐Disubstituted Pyrrolidin‐2‐ones

Author(s) -

Hashmi A. Stephen K.,

Yang Weibo,

Yu Yang,

Hansmann Max M.,

Rudolph Matthias,

Rominger Frank

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201207287

Subject(s) - chemistry , computer science , tandem , combinatorial chemistry , stereochemistry , transformation (genetics) , biochemistry , engineering , gene , aerospace engineering

Mobile : The title reaction affords diastereomerically pure 3,4‐disubstituted pyrrolidin‐2‐ones, which are important structural motifs in natural products, in good to high yields. Mechanistic investigations suggest the transformation proceeds through a tandem 1,3‐acyloxy migration and a subsequent 1,5‐acyloxy migration. DCE=1,2‐dichloroethane, IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research