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Quantifying Analytes in Paper‐Based Microfluidic Devices Without Using External Electronic Readers
Author(s) -
Lewis Gregory G.,
DiTucci Matthew J.,
Phillips Scott T.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207239
Subject(s) - analyte , computer science , wetting , microfluidics , reagent , nanotechnology , process engineering , chromatography , chemistry , materials science , engineering , organic chemistry , composite material
A matter of time : Two quantitative assays are presented that require only measurements of time and the ability to see and/or count to quantify the presence of a specific analyte. The strategies rely on specific changes in wetting properties of paper when a hydrophobic detection reagent (compound 1 ) reacts with a desired analyte to produce hydrophilic products. This change in wetting properties enables selective and quantitative detection of the analyte.