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Transition‐Metal‐Free Aerobic Oxidative Cleavage of CC Bonds in α‐Hydroxy Ketones and Mechanistic Insight to the Reaction Pathway
Author(s) -
Liu Hui,
Dong Chao,
Zhang Zeguang,
Wu Peiyu,
Jiang Xuefeng
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207206
Subject(s) - oxidizing agent , chemistry , reaction mechanism , reagent , dimer , isotopic labeling , combinatorial chemistry , mechanism (biology) , stereochemistry , catalysis , organic chemistry , philosophy , epistemology
Clear cut : For the title reaction, O 2 , the ideal oxidant, was used as the only oxidizing reagent. The dimer intermediate (see scheme) and isotopic labeling control experiments with 18 O 2 partially disclosed the reaction mechanism.