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MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a Gd III ‐dota‐en‐pba Imaging Reporter
Author(s) -
Geninatti Crich Simonetta,
Alberti Diego,
Szabo Ibolya,
Aime Silvio,
Djanashvili Kristina
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207131
Subject(s) - sialic acid , dota , melanoma , cancer research , chemistry , malignancy , reporter gene , microbiology and biotechnology , biochemistry , medicine , pathology , biology , gene , chelation , gene expression , organic chemistry
By design : The novel MRI reporter Gd III ‐dota‐en‐pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16‐F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.