z-logo
Premium
MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a Gd III ‐dota‐en‐pba Imaging Reporter
Author(s) -
Geninatti Crich Simonetta,
Alberti Diego,
Szabo Ibolya,
Aime Silvio,
Djanashvili Kristina
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207131
Subject(s) - sialic acid , dota , melanoma , cancer research , chemistry , malignancy , reporter gene , microbiology and biotechnology , biochemistry , medicine , pathology , biology , gene , chelation , gene expression , organic chemistry
By design : The novel MRI reporter Gd III ‐dota‐en‐pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16‐F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here