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2′‐SCF 3 Uridine—A Powerful Label for Probing Structure and Function of RNA by 19 F NMR Spectroscopy
Author(s) -
Fauster Katja,
Kreutz Christoph,
Micura Ronald
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207128
Subject(s) - riboswitch , rna , chemistry , biomolecule , nuclear magnetic resonance spectroscopy , fluorine 19 nmr , uridine , molecule , combinatorial chemistry , computational biology , nanotechnology , stereochemistry , biophysics , non coding rna , biochemistry , gene , biology , materials science , organic chemistry
Fluorishing : The Togni reagent allows efficient synthetic access to fluorine‐labeled RNA molecules (see picture). These are in turn highly useful for NMR spectroscopic analyses of secondary and tertiary structures, RNA–protein interactions, and functionality of riboswitch modules.