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Tracking the Bioreduction of Disulfide‐Containing Cationic Dendrimers
Author(s) -
Brülisauer Lorine,
Kathriner Nadia,
Prenrecaj Mark,
Gauthier Marc A.,
Leroux JeanChristophe
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207070
Subject(s) - dendrimer , cationic polymerization , gene delivery , chemistry , transfection , disulfide bond , polymer , drug delivery , nanotechnology , combinatorial chemistry , tracking (education) , biophysics , gene , organic chemistry , biochemistry , materials science , biology , psychology , pedagogy
Disulfides enhance the transfection efficacy and reduce the toxicity of cationic gene delivery polymers. A quantitative analysis is provided of the bioreduction of a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge is indispensible for understanding and optimizing bioreducible drug and gene delivery systems.