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Using Smell To Triage Samples in Point‐of‐Care Assays
Author(s) -
Mohapatra Hemakesh,
Phillips Scott T.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201207008
Subject(s) - ethanethiol , computer science , triage , feature (linguistics) , reagent , point of care , trustworthiness , odor , information retrieval , chemistry , chromatography , medicine , internet privacy , medical emergency , pathology , linguistics , philosophy , organic chemistry
Smell of success : Reagent 1 provides the dual readouts of odor (ethanethiol) and fluorescence (derivative of 7‐hydroxycoumarin) and can be used in down‐selection assays based on smell and quantitative fluorescence assays of the samples that give a positive result. An important feature of 1 is the matched sensitivity of the two outputs. This reagent is designed for use in resource‐limited settings and is demonstrated in assays that detect enzymes.