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Cover Picture: Epidithiol Formation by an Unprecedented Twin Carbon–Sulfur Lyase in the Gliotoxin Pathway (Angew. Chem. Int. Ed. 40/2012)
Author(s) -
Scharf Daniel H.,
Chankhamjon Pranatchareeya,
Scherlach Kirstin,
Heinekamp Thorsten,
Roth Martin,
Brakhage Axel A.,
Hertweck Christian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206982
Subject(s) - gliotoxin , chemistry , int , aspergillus fumigatus , adduct , enzyme , biosynthesis , biochemistry , stereochemistry , microbiology and biotechnology , biology , organic chemistry , computer science , operating system
The pathogenic fungus Aspergillus fumigatus produces the infamous toxin, gliotoxin. In their Communication on page 10064 ff., C. Hertweck and co‐workers elucidate a key step in the biosynthesis of the transannular disulfide bridge that is indispensable for the deleterious effects of gliotoxin. A single enzyme, GliI, is capable of concomitantly cleaving two CS bonds in a bis(cysteinyl) adduct, to yield a dithiol, ammonia, and pyruvate. Electron micrograph kindly provided by J. Schmaler‐Ripcke, Jena.