Cover Picture: Epidithiol Formation by an Unprecedented Twin Carbon–Sulfur Lyase in the Gliotoxin Pathway (Angew. Chem. Int. Ed. 40/2012) | Zendy

Scharf Daniel H. | Zendy; Chankhamjon Pranatchareeya | Zendy; Scherlach Kirstin | Zendy; Heinekamp Thorsten | Zendy; Roth Martin | Zendy; Brakhage Axel A. | Zendy; Hertweck Christian | Zendy

Premium

Cover Picture: Epidithiol Formation by an Unprecedented Twin Carbon–Sulfur Lyase in the Gliotoxin Pathway (Angew. Chem. Int. Ed. 40/2012)

Author(s) -

Scharf Daniel H.,

Chankhamjon Pranatchareeya,

Scherlach Kirstin,

Heinekamp Thorsten,

Roth Martin,

Brakhage Axel A.,

Hertweck Christian

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206982

Subject(s) - gliotoxin , chemistry , int , aspergillus fumigatus , adduct , enzyme , biosynthesis , biochemistry , stereochemistry , microbiology and biotechnology , biology , organic chemistry , computer science , operating system

The pathogenic fungus Aspergillus fumigatus produces the infamous toxin, gliotoxin. In their Communication on page 10064 ff., C. Hertweck and co‐workers elucidate a key step in the biosynthesis of the transannular disulfide bridge that is indispensable for the deleterious effects of gliotoxin. A single enzyme, GliI, is capable of concomitantly cleaving two CS bonds in a bis(cysteinyl) adduct, to yield a dithiol, ammonia, and pyruvate. Electron micrograph kindly provided by J. Schmaler‐Ripcke, Jena.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research