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Metallo‐Foldamers with Backbone‐Coordinative Oxime Peptides: Control of Secondary Structures
Author(s) -
Tashiro Shohei,
Matsuoka Koji,
Minoda Ai,
Shionoya Mitsuhiko
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206968
Subject(s) - oxime , chemistry , peptide , protein secondary structure , stereochemistry , cyclic peptide , crystallography , organic chemistry , biochemistry
Metal‐mediated secondary structures of peptide‐based foldamers were constructed using artificial backbone‐coordinative oxime peptides. Complexation of the peptides with Pd II afforded several mononuclear and dinuclear secondary structures such as helices and hairpins as confirmed by single‐crystal XRD and NMR analyses (see picture).