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Synthetic Strategy for Cyclic Amines: A Stereodefined Cyclic N,O‐Acetal as a Stereocontrol and Diversity‐Generating Element
Author(s) -
Kim Haejin,
Lim Wontaeck,
Im Donghong,
Kim Donggil,
Rhee Young Ho
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206967
Subject(s) - acetal , hydroamination , metathesis , stereochemistry , computer science , combinatorial chemistry , intramolecular force , chemistry , organic chemistry , polymerization , polymer
In control : A new synthetic strategy towards cyclic amines was developed and exploits a stereodefined cyclic N,O‐acetal as the key stereocontrol and diversity‐generating element. The cyclic N,O‐acetal was prepared from the sequential asymmetric hydroamination of an alkoxyallene with the chiral ligand L* , and ring‐closing metathesis. The stereochemical integrity of the labile N,O‐acetal was conserved in all catalytic transformations.