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Intrinsically Copper‐64‐Labeled Organic Nanoparticles as Radiotracers
Author(s) -
Liu Tracy W.,
MacDonald Thomas D.,
Shi Jiyun,
Wilson Brian C.,
Zheng Gang
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206939
Subject(s) - copper , nanoparticle , chemistry , nanotechnology , materials science , radiochemistry , organic chemistry
PET friendly : Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one‐pot, high‐yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activity ever reported for a 64 Cu‐labeled nanoparticle. These 64 Cu‐porphysomes can be accurately and noninvasively tracked in vivo.