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Potent Small‐Molecule Suppression of Oxacillin Resistance in Methicillin‐Resistant Staphylococcus aureus
Author(s) -
Harris Tyler L.,
Worthington Roberta J.,
Melander Christian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206911
Subject(s) - staphylococcus aureus , minimum inhibitory concentration , methicillin resistant staphylococcus aureus , antibiotics , microbiology and biotechnology , antimicrobial , adjuvant , small molecule , bacteria , medicine , biology , genetics , immunology
Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi‐drug‐resistant bacteria, such as MRSA, to clinically available antibiotics are a promising alternative to the development of novel antimicrobials. Pictured is a potent small molecule ( 1 ) that, at sub‐minimum inhibitory concentration (sub‐MIC) levels, lowers the MIC of oxacillin ( 2 ) against a number of MRSA strains by up to 512‐fold.
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