Scalable, Enantioselective Synthesis of Germacrenes and Related Sesquiterpenes Inspired by Terpene Cyclase Phase Logic | Zendy

Foo Klement | Zendy; Usui Ippei | Zendy; Götz Daniel C. G. | Zendy; Werner Erik W. | Zendy; Holte Dane | Zendy; Baran Phil S. | Zendy

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Scalable, Enantioselective Synthesis of Germacrenes and Related Sesquiterpenes Inspired by Terpene Cyclase Phase Logic

Author(s) -

Foo Klement,

Usui Ippei,

Götz Daniel C. G.,

Werner Erik W.,

Holte Dane,

Baran Phil S.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206904

Subject(s) - library science , chemistry , engineering , computer science

Terpene cyclase phase : Inspired by this logic, a scalable and enantioselective divergent synthesis of germacrane‐type sesquiterpenes is developed. Salient features of this work include: 1) the direct ring closure of a farnesol derivative to the 10‐membered carbocycle 1 , and 2) subsequent synthetic operations on 1 to gain access to different bicyclic frameworks such as guaianes, cadinanes, selinanes, and elemenes.

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