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Bioorthogonal Copper‐Free Click Chemistry In Vivo for Tumor‐Targeted Delivery of Nanoparticles
Author(s) -
Koo Heebeom,
Lee Sangmin,
Na Jin Hee,
Kim Sun Hwa,
Hahn Sei Kwang,
Choi Kuiwon,
Kwon Ick Chan,
Jeong Seo Young,
Kim Kwangmeyung
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206703
Subject(s) - bioorthogonal chemistry , in vivo , click chemistry , chemistry , azide , nanoparticle , sialic acid , nanotechnology , n acetylneuraminic acid , copper , combinatorial chemistry , biochemistry , materials science , organic chemistry , microbiology and biotechnology , biology
Right on target : An in vivo tumor‐targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an in vivo bioorthogonal copper‐free click reaction.