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A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells
Author(s) -
Lee Jungwoon,
Xia Yan,
Son MiYoung,
Jin Guanghai,
Seol Binna,
Kim MinJeong,
Son Myung Jin,
Do Misol,
Lee Minho,
Kim Dongsup,
Lee Kyeong,
Cho Yee Sook
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206691
Subject(s) - reprogramming , induced pluripotent stem cell , somatic cell , biology , human induced pluripotent stem cells , microbiology and biotechnology , genetics , embryonic stem cell , gene
Booster of pluripotency : RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).