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Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide
Author(s) -
Willwacher Jens,
KauschBusies Nina,
Fürstner Alois
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206670
Subject(s) - antimitotic agent , computer science , closing (real estate) , key (lock) , information retrieval , biology , political science , microtubule , tubulin , law , microbiology and biotechnology , computer security
Subtle but distinctive : The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring‐closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1 H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.