Premium
Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide
Author(s) -
Willwacher Jens,
KauschBusies Nina,
Fürstner Alois
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206670
Subject(s) - antimitotic agent , computer science , closing (real estate) , key (lock) , information retrieval , biology , political science , microtubule , tubulin , law , microbiology and biotechnology , computer security
Subtle but distinctive : The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring‐closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1 H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom