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Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen
Author(s) -
Graupner Katharina,
Scherlach Kirstin,
Bretschneider Tom,
Lackner Gerald,
Roth Martin,
Gross Harald,
Hertweck Christian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206658
Subject(s) - virulence , mushroom , antifungal , virulence factor , microbiology and biotechnology , pathogen , mass spectrometry , antifungal drugs , biology , chemistry , gene , genetics , botany , chromatography
Caught in the act : Imaging mass spectrometry of a button mushroom (see picture) infected with the soft rot pathogen Janthinobacterium agaricidamnosum in conjunction with genome mining revealed jagaricin as a highly antifungal virulence factor that is not produced under standard cultivation conditions. The structure of jagaricin was rigorously elucidated by a combination of physicochemical analyses, chemical derivatization, and bioinformatics.