Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen | Zendy

Graupner Katharina | Zendy; Scherlach Kirstin | Zendy; Bretschneider Tom | Zendy; Lackner Gerald | Zendy; Roth Martin | Zendy; Gross Harald | Zendy; Hertweck Christian | Zendy

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Imaging Mass Spectrometry and Genome Mining Reveal Highly Antifungal Virulence Factor of Mushroom Soft Rot Pathogen

Author(s) -

Graupner Katharina,

Scherlach Kirstin,

Bretschneider Tom,

Lackner Gerald,

Roth Martin,

Gross Harald,

Hertweck Christian

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206658

Subject(s) - virulence , mushroom , antifungal , virulence factor , microbiology and biotechnology , pathogen , mass spectrometry , antifungal drugs , biology , chemistry , gene , genetics , botany , chromatography

Caught in the act : Imaging mass spectrometry of a button mushroom (see picture) infected with the soft rot pathogen Janthinobacterium agaricidamnosum in conjunction with genome mining revealed jagaricin as a highly antifungal virulence factor that is not produced under standard cultivation conditions. The structure of jagaricin was rigorously elucidated by a combination of physicochemical analyses, chemical derivatization, and bioinformatics.

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